I love the products! They are amazing.
Very nice & unscented. My shipments always come quickly.
Very effective for combating rudiness.
Yet another fantastic product from Vital Therapy!
We will send you an email to reset your password.
Use this text to share announcements or information with your customers.
We will send you an email to reset your password.
Menopause hitting you like a freight train? Hot flashes that make you want to live in a freezer, brain fog that has you forgetting why you walked into a room, and bones that feel like they're turning to dust? You need more than just gentle support—you need the power duo of estrogen.
Our Bi-Estro Cream combines the best of both worlds with an 80/20 blend of bioidentical Estriol and Estradiol. Think of Estriol as the gentle, supportive friend and Estradiol as the powerhouse that gets things done. Together, they work to ease hot flashes, support bone density, boost your mood, and bring back that spark you thought was gone for good.
Each dose (4 pumps or 1/4 teaspoon) delivers approximately 1 mg of Estriol USP and 0.25 mg of Estradiol USP—just enough to help your body remember what balanced hormones feel like. The transdermal delivery means it absorbs through your skin and gets to work without taxing your digestive system.
Apply 4 pumps (or 1/4 teaspoon) to clean, dry skin on areas like the back of your knees, inner arms, upper chest, neck, or face. Rotate your application areas daily so your skin doesn't get too familiar with the routine.
Important: Always use this with a natural progesterone cream (like our Natural Progesterone Lotion) to keep your hormones balanced. Estrogen without progesterone is like a car without brakes—not a good idea.
Active Ingredients:
Nourishing Base:
Q: What's the difference between this and regular Estrogen Cream?
A: Our regular Estrogen Cream contains only Estriol (the gentlest form). Bi-Estro Cream adds Estradiol to the mix, which is more potent and especially helpful for severe hot flashes, bone density concerns, and when you need a stronger estrogen boost.
Q: Do I really need to use progesterone with this?
A: Yes! If you still have your uterus, you absolutely need to balance estrogen with progesterone. This helps protect your uterine lining and keeps everything in harmony. We recommend pairing this with our Natural Progesterone Lotion.
Q: Can I use this if I've had breast cancer or have a family history?
A: This is a conversation for your healthcare provider. Bioidentical hormones are different from synthetic ones, but your personal health history matters. Always consult your doctor before starting any hormone support.
Q: How long until I notice a difference?
A: Many women notice improvements in hot flashes and sleep within the first few weeks. For bone health, mood, and overall well-being, give it 60-90 days of consistent use.
Q: Can I apply multiple products to the same spot?
A: Don't use multiple products on the same site. Rotate your application areas so each product gets its own real estate—your skin will absorb them better that way.
Q: What if I'm still in perimenopause?
A: Bi-Estro is typically best for women who are fully menopausal and estrogen-deficient. If you're still cycling or in early perimenopause, you might benefit more from our Peri-Menopause Relief Cream or single Estrogen Cream. Check with your healthcare provider.
Safety: Not recommended during pregnancy or lactation. Consult a healthcare professional before use, especially if you have a history of hormone-sensitive conditions or are taking medication. No animal testing.
Legal Disclaimer: This information is for educational purposes only and has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Adding product to your cart
Excellent product that addressed all the post-menopausal symptoms for the better, specially, replenishes the vaginal wall's thickness and natural moisture.
Great product. Kept my estrogen and progesterone levels up when my compounded meds were running late. This is an affordable back up plan that works according to my lab results. I just wish it had testosterone in it .. but testosterone is a schedule 3 drug
Great product Emu Plus and quality! Accurate description and works as stated!
Boost Energy
I have PCOS and adrenaline fatigue. This has significantly helped! I no longer feel like I’m dragging through the day. I sleep better at night, my workouts are better. It was a great find!!
See our Refund and Return policy page Click Here
In business for 20 plus year owned and operated by wonder women.
Authorize.net Secure Processing. We accept all major credit cards.
I love the products! They are amazing.
Very nice & unscented. My shipments always come quickly.
Very effective for combating rudiness.
Yet another fantastic product from Vital Therapy!